2-(2-Methoxy Ethoxy)-Benzene Sulfonamide
Methyl 3,4,5-trimethoxybenzoate
CAS: 1916-07-0
Molecular Formula: C11H14O5
2-(2-Methoxy Ethoxy)-Benzene Sulfonamide - Names and Identifiers
2-(2-Methoxy Ethoxy)-Benzene Sulfonamide - Physico-chemical Properties
| Molecular Formula | C11H14O5 |
| Molar Mass | 226.23 |
| Density | 1.2668 (rough estimate) |
| Melting Point | 82-84 °C (lit.) |
| Boling Point | 274-275 °C (lit.) |
| Flash Point | 274-275°C |
| Solubility | DMSO:45 mg/mL (198.91 mM) |
| Vapor Presure | 0.00538mmHg at 25°C |
| Appearance | Powder |
| Color | White to Off-White |
| BRN | 2218156 |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.5140 (estimate) |
| MDL | MFCD00008431 |
| Physical and Chemical Properties | Melting Point 81-85°C boiling point 274-275°C |
| Use | Used as a pharmaceutical intermediate, is the main raw material of anti Anxiety drug trimetazidine, gastrointestinal drug trimebutine maleate and so on |
2-(2-Methoxy Ethoxy)-Benzene Sulfonamide - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| RTECS | DI0820000 |
| TSCA | Yes |
| HS Code | 29189900 |
| Hazard Note | Irritant |
2-(2-Methoxy Ethoxy)-Benzene Sulfonamide - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| Biological activity | Methyl 3,4,5-trimethoxybenzoate is synthesized with Gallic acid as the starting material, and is mainly used to produce trimethoprim (TMP), sulfa synergist intermediates, and many other drugs. |
| use | this product is an intermediate of the antibacterial synergistic drug trimethoprim. Used as a pharmaceutical intermediate, it is the main raw material for anti-anxiety drug trimetozidine, gastrointestinal drug trimebutine maleate, etc. |
| Production method | Made by methylation reaction of gallic acid and dimethyl sulfate. Add water, gallic acid and dimethyl sulfate to the reaction pot, add sodium hydroxide solution dropwise at 15-35 ℃, and stir at about 40 ℃ for half an hour. The second batch of dimethyl sulfate was added, and sodium hydroxide solution was added dropwise at about 40 ℃ to pH 8-9. After continuing the reaction for 1h, it was cooled, filtered, washed and dried to obtain methyl trimethoxybenzoate with a yield of more than 90%. The above methylation and esterification reactions can also be carried out in water and chloroform using tetrabutylammonium bromide as a phase transfer catalyst. The product can also be prepared by using tannic acid as raw material or by esterification of 3,4, 5-trimethoxybenzoic acid and methanol. |
Last Update：2024-04-09 21:11:58
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